| Title: Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Author(s): Inoue N, Nagao K, Hirata J, Wang YM, Yanagita T. Source: Biochem Biophys Res Commun. 2004 Oct 15;323(2):679-84. Content: Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840-8502, Japan. Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic acid found in beef, lamb, and dairy products. CLA has attracted considerable attention over the past several decades because of its potentially beneficial biologic effects, including protective effects against several cancers, atherosclerosis, and obesity. In previous studies, we provided evidence that dietary CLA could prevent the development of obesity-related hypertension in obese animals. Here, we show that CLA suppresses the development of non-obese essential hypertension in spontaneously hypertensive rats (SHRs). After 4 weeks of feeding with CLA, the increase of systolic blood pressure was significantly suppressed compared with rats fed linoleic acid. Abdominal adipose tissue weight was also significantly lowered in CLA-fed SHRs. Content of arachidonic acid, the substrate of eicosanoid production, was not changed, but accumulation of oleic acid, the lipogenesis end-product, was markedly decreased in the membrane phospholipids of CLA-fed SHRs. In addition, we found increased level of plasma adiponectin, suggested as a regulatory factor of hypertension, through the enhancement of mRNA expression in CLA-fed SHRs. We speculate that the antihypertensive effect of dietary CLA may be due to the increase of plasma adiponectin level and associated with the alleviation of membrane abnormality in SHRs. Copyright 2004 Elsevier Inc. More/Expanded Article Information: [ click here ] Click Here To View A Conjugated Linoleic Acid (CLA) Supplier Website! |
|
This site is a service of CCWEBGROUP that provides and reports interesting information that is available to the general public. CCWEBGROUP is not in any way involved in performing the scientific studies, completing the analyses, nor evaluating the results.
Many studies reported herein have been performed on laboratory animals and not on humans. While some results of animal trials are later found to be similar in human trials, we have no way of knowing whether or not this will be the case. This information is not presented as medical advice and no conclusions regarding the effectiveness or lack of such should be drawn from this information. As with any information that pertains to your health, please discuss your questions and/or conclusions with your physician or healthcare provider. You can order Tonalin CLA for fat loss! |
|
About Us | Contact Us | Privacy Policy | Return Policy | Resource Links | Site Map copyright © 2005 :: ccwebgroup :: all rights reserved |